3rd Party Research
U.S. EPA. “Why Indoor Air Quality is Important to Schools.”
https://www.epa.gov/iaq-schools/why-indoor-air-quality-important-schools
Relevance: EPA states that children take in more air, food, and liquid per unit body weight than adults, supporting the claim that kids inhale more air per kilogram and are more vulnerable to airborne toxics.
European Environment Agency. “Air pollution.”
https://www.eea.europa.eu/en/topics/in-depth/air-pollution
Relevance: EEA explains that children have higher ventilation rates per body mass and developing organs, reinforcing their heightened susceptibility to air pollution.
U.S. EPA. Exposure Factors Handbook, Chapter 6: Inhalation Rates (PDF).
https://www.epa.gov/sites/default/files/2015-09/documents/efh-chapter06.pdf
Relevance: The standard reference for age specific inhalation rates. Documents higher breathing rates per body weight in children, which underpins pediatric exposure assessments.
MSD Manual Professional Edition. “Pharmacokinetics in Children.”
https://www.msdmanuals.com/professional/pediatrics/principles-of-drug-treatment-in-children/pharmacokinetics-in-children
Relevance: Explains that drug metabolism and elimination mature across childhood, with many hepatic Phase I pathways approaching adult activity by adolescence. Supports careful wording about maturation rather than a single “fully developed” age.
Hines RN. “The ontogeny of human drug metabolizing enzymes.” Drug Metab Dispos. 2008.
https://dmd.aspetjournals.org/content/36/12/2507
Relevance: Foundational review detailing age specific expression and activity of CYP enzymes and other pathways from fetal life through adolescence, showing that maturation is gradual and enzyme dependent.
Kearns GL et al. “Developmental pharmacology.” New England Journal of Medicine, 2003.
https://www.nejm.org/doi/full/10.1056/NEJMra035092
Relevance: Classic review summarizing how growth and maturation alter absorption, distribution, metabolism, and excretion in children, reinforcing that detox capacity evolves through the teen years.
U.S. EPA. “Formaldehyde.”
https://www.epa.gov/formaldehyde
Relevance: Identifies major sources and summarizes irritation and cancer concerns, justifying formaldehyde as a priority indoor VOC.
ATSDR. Toxicological Profile for Formaldehyde (PDF).
https://www.atsdr.cdc.gov/toxprofiles/tp111.pdf
Relevance: Comprehensive toxicology covering respiratory irritation, sensitization, and carcinogenicity, providing authoritative backing for formaldehyde health effects.
ATSDR. Toxicological Profile for Benzene (PDF).
https://www.atsdr.cdc.gov/toxprofiles/tp3.pdf
Relevance: Documents hematopoietic toxicity and the link between chronic benzene exposure and leukemia, especially AML. Supports the bone marrow and blood effects stated.
ATSDR / NCBI Bookshelf. Toxicological Profile for Toluene.
https://www.ncbi.nlm.nih.gov/books/NBK598002/
Relevance: Summarizes neurologic and sensory effects from acute and chronic exposure, including neurobehavioral outcomes. Directly supports the nervous system impacts noted.
ATSDR. Toxicological Profile for Xylenes (PDF).
https://www.atsdr.cdc.gov/toxprofiles/tp71.pdf
Relevance: Details irritation of eyes and airways and central nervous system effects at higher exposure, and discusses liver and kidney endpoints. Supports inclusion of xylene as a home relevant solvent risk.
OEHHA. “Acetaldehyde.”
https://oehha.ca.gov/chemicals/acetaldehyde
Relevance: California’s tox profile page on sources and endpoints, including respiratory irritation and cancer considerations, supporting the acetaldehyde callout.
OEHHA. “Appendix D. Individual Acute, 8 Hour, and Chronic Reference Exposure Level Summaries” (Acetaldehyde) (PDF).
https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd1final.pdf
Relevance: Provides numerical health based reference levels and toxicologic endpoints for acetaldehyde, supporting the emphasis on airway irritation as a critical effect.
World Health Organization. “Ambient air pollution and health.”
https://www.who.int/news-room/fact-sheets/detail/ambient-(outdoor)-air-quality-and-health
Relevance: WHO summarizes global evidence that children and older adults are more susceptible to air pollution, with dominant cardiorespiratory impacts. Substantiates the vulnerability framing for elders.
Alvarez EG et al. “Unexpectedly High Indoor Hydroxyl Radical Concentrations.” Science, 2013.
https://www.science.org/doi/10.1126/science.1232003
Relevance: Shows that indoor environments can sustain meaningful OH levels that rapidly oxidize VOCs, linking outdoor air cleaning chemistry to indoor spaces.
Alvarez E et al. “Unexpectedly high indoor hydroxyl radical concentrations associated with nitrous acid.” PNAS, 2013.
https://www.pnas.org/doi/10.1073/pnas.1308310110
Relevance: Mechanistic field and chamber work showing HONO photolysis as a strong indoor OH source, complementing the Science finding.
Reidy E et al. “HOMEChem: House Observations of Microbial and Environmental Chemistry.”
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10212288/
Relevance: Real house experiments demonstrating rapid formation of oxidants including OH during day to day activities and fast indoor VOC transformations. Provides field based context that indoor OH chemistry is significant in occupied homes.
Paños Crespo A et al. “Evaluation of the efficacy of hydroxyl radical release for disinfection of the air and surfaces in the dental clinic.” Med Oral Patol Oral Cir Bucal, 2023.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10522949/
Relevance: In situ clinical evaluation reporting reductions in airborne bacteria and molds and lower surface counts during controlled OH release in an operating dental clinic, connecting chemistry to measurable hygiene outcomes.